40155751ff1be06b7b704b85eece5a42b4f5b0e

welcome

We are glad to welcome you to our website

ECG monitoring is recommended, along with drugs that may prolong the QT interval. Comment: Coadministration of tacrolimus with cyclosporine may increase the risk of nephrotoxicity and immunosuppressive effects.

Additionally, both agents are CYP3A4 and P-gp substrates and may elevate serum levels of either agent when coadministered. Discontinue tacrolimus or cyclosporine therapy at least 24 hours before initiating therapy with the other agent. Comment: Concomitant administration increases risk of nephrotoxicity. The use of dronedarone in combination with other medications that can prolong the QT interval is considered contraindicated.

Dose adjustment may be required with strong P-gp inhibitors. Decrease eluxadoline dose to 75 mg PO BID if coadministered with OATP1B1 inhibitors. Avoid coadministration with erdafitinib and sensitive CYP3A4 substrates with narrow therapeutic indices.

Erdafitinib may altered plasma concentrations of CYP3A4 substrates, leading to either loss of activity or increased toxicity of the substrate. If coadministration unavoidable, separate administration by at least 6 hr before or after administration of P-gp substrates with narrow therapeutic index. Avoid coadministration of fexinidazole with drugs known to block potassium channels or prolong QT interval. Coadministration may increase risk for adverse effects of CYP3A4 substrates.

Immunosuppressive therapies, including irradiation, antimetabolites, alkylating agents, cytotoxic drugs, and corticosteroids (used in greater than physiologic doses), may reduce the immune responses to vaccines. Immunosuppressive drugs may reduce the immune response to influenza vaccine. Avoid coadministration of QTc prolonging drugs with ivosidenib or replace with alternate therapies. If coadministration of a QTc prolonging drug is unavoidable, monitor for increased risk of QTc interval prolongation.

Avoid coadministration of sensitive CYP3A4 substrates with ivosidenib or replace with alternative therapies. If coadministration is unavoidable, monitor patients for loss of therapeutic effect of these drugs. Avoid coadministration with sensitive CYP3A substrates. If coadministration unavoidable, monitor for adverse reactions and reduce CYP3A substrate dose in accordance with product labeling.

Avoid use of lorlatinib with CYP3A substrates, where minimal concentration changes may lead to serious therapeutic failures of the substrate. If concomitant use is unavoidable, increase CYP3A substrate dosage in accordance with approved product labeling. Lumacaftor is a strong inducer of CYP3A. Avoid coadministration with sensitive CYP3A substrates or CYP3A substrates with a narrow therapeutic index.

Avoid coadministration with drugs that prolong QT interval, which could increase risk for developing torsade de pointes-type ventricular tachycardia. Allow sufficient washout time of drugs that are known to prolong the QT interval before administering macimorelin.

Mefloquine may enhance the QTc prolonging effect of high risk QTc prolonging agents. Concomitant therapy is expected to increase the risk of immunosuppression. Use caution when switching patients from long-acting therapies with immune effects.

Coadministration of pexidartinib (a CYP3A4 inducer) with sensitive CYP3A substrates may lead to serious therapeutic failures. If concomitant use is unavoidable, increase the CYP3A substrate dosage in accordance with approved product labeling.

Immunosuppressants may interfere with development of active immunity. Comment: OATP1B1 and OATP1B3 transport inhibitors may increase systemic exposure of revefenacin's active metabolite. Coadministration of riociguat (substrate of CYP isoenzymes 1A1, 2C8, 3A, 2J2) with strong CYP inhibitors may require a decreased initial dose of 0. If use is unavoidable, refer to the prescribing information of the CYP3A4 substrate for dosage modificationssotorasib will decrease the level or effect of tacrolimus by P-glycoprotein (MDR1) efflux transporter.

If use is unavoidable, refer to the prescribing information of the P-gp substrate for dosage modifications. St John's Wort decreases levels of tacrolimus by increasing metabolism. Concurrent use of toremifene with agents causing QT prolongation should be avoided. If concomitant use is required it's recommended that toremifene be interrupted. If interruption not possible, patients requiring therapy with a drug that prolongs QT should be closely monitored. ECGs should be obtained for high risk patients.

Avoid concomitant use of tucatinib with CYP3A substrates, where minimal concentration changes may lead to serious or life-threatening toxicities.

If unavoidable, reduce CYP3A substrate dose according to product labeling. Monitor more closely for signs of venetoclax toxicities. In vitro data suggest venetoclax may inhibit P-gp substrates at therapeutic dose levels in the gut. Avoid coadministration of narrow therapeutic index P-gp substrates with venetoclax. If a narrow therapeutic index P-gp substrate must be used, it should be taken at least 6 hr before venetoclax. Voxelotor increases systemic exposure of sensitive CYP3A4 substrates.

Avoid coadministration with sensitive CYP3A4 substrates with a narrow therapeutic index.